Faculty

JENNIFER OLIVEROS MANILAY, PhD
Assistant Professor
School of Natural Sciences

Email: jmanilay@ucmerced.edu
Phone: (209)228-4175
Fax: (209)228-4053
www: Lab website

Education:

Ph.D. Harvard University, Immunology, Division of Medical Sciences, June 1999
B.A. UC Berkeley, Molecular and Cell Biology (Minor in Ethnic Studies), 1992

Research Interests (View)

As a developmental immunologist, my research focuses on the mechanisms that control cell fate decisions in the immune system. My current topic of study is the development of T lymphocytes, important components of immune defense against pathogens.
Representative Publications (View)

  1. Manilay JO, Anderson AC, Kang, C and Robey EA. (2005). Impairment of thymocyte development by dominant-negative Kuzbanian (ADAM-10) is rescued by the Notch ligand, Delta-1, Journal of Immunology, 174::6732-41.
  2. Yang L-T, Nichols JT, Yao C, Manilay JO, Robey EA, and Weinmaster G. (2005). Fringe glycosyltransferases modulate Notch1 proteolysis induced by Delta1 and Jagged1. Molecular Biology of the Cell 16: 927-942.
  3. Zhao Y, Ohdan H, Manilay JO, Sykes M. (2003). NK cell tolerance in mixed allogeneic chimeras. Journal of Immunology, 2003, 170 (11): 5398-5405.
  4. Manilay JO. Waneck GL. Sykes M. (1999). Levels of Ly-49 receptor expression are determined by the frequency of interactions with MHC ligands: Evidence against receptor calibration to a "useful" level. Journal ofImmunology. 163(5):2628-2633.
  5. Manilay JO. Waneck GL. Sykes M. (1999). Altered expression of Ly-49 receptors on NK cells developing in mixed allogeneic bone marrow chimeras. International Immunology. 10(12):1943-1955.
  6. Manilay JO. Sykes M. (1998). Natural killer cells and their role in graft rejection. Current Opinion in Immunology. 10(5):532-538.
  7. Manilay JO. Pearson DA. Sergio JJ. Swenson KG. Sykes M. (1998). Intrathymic deletion of alloreactive T cells in mixed bone marrow chimeras prepared with a nonmyeloablative conditioning regimen. Transplantation. 66(1):96-102